MF and Sézary syndrome treatment

Stage-specific expert consensus

EORTC recommendations combine published evidence with expert consensus. Their options are not interchangeable prescriptions; selection depends on disease compartment, prior response, comorbidities and availability.

Early-stage MF

Skin-directed options include topical corticosteroids, chlormethine, narrowband UVB and PUVA. Localized radiotherapy may suit localized disease; observation can be considered for selected limited patch disease. Refractory disease may need other approaches.

Advanced or refractory disease

Specialist options include systemic treatments, photopheresis and radiotherapy, often alongside skin-directed care. Choice depends on stage and the involved compartments. The app does not choose an agent, dose or sequence.

Allogeneic transplantation requires dedicated eligibility and timing assessment; it is not a routine recommendation for every advanced-stage patient.

Scope and unanswered questions

App convention: this is a discussion guide, not a prescribing protocol or a complete drug catalog. Current local approvals, monitoring and trial eligibility must be checked for an individual treatment.

Children and adolescents require age-specific guidance.